Gestational Diabetes Tied to Increased Sleep Apnea Risk

Gestational Diabetes Tied to Increased Sleep Apnea Risk

Pregnant women with gestational diabetes lose over an hour of sleep each night

FRIDAY, Sept. 6 (HealthDay News) -- There is a strong association between gestational diabetes mellitus (GDM) and obstructive sleep apnea (OSA), according to a study published online Aug. 21 in the Journal of Clinical Endocrinology & Metabolism.

Sirimon Reutrakul, M.D., from the Rush University Medical Center in Chicago, and colleagues used polysomnography in three age- and race-matched groups of women: 15 non-pregnant women without diabetes (NP-NGT), 15 pregnant women with normal glucose tolerance (P-NGT), and 15 pregnant women with GDM (P-GDM). Pregnant women were evaluated during the late second to early third trimester.

The researchers found that P-NGT women had a higher apnea hypopnea index (AHI; median, 2.0 versus 0.5; P = 0.03), more disrupted sleep as reflected by a higher wake time after sleep onset (median, 66 versus 21 minutes; P < 0.01), and a higher microarousal index (median, 16.4 versus 10.6; P = 0.01), compared with NP-NGT women. P-GDM women had significantly lower total sleep time (median, 397 versus 464 minutes; P = 0.02) and a higher AHI (median, 8.2 versus 2.0; P = 0.05) compared to P-NGT women. For P-GDM women, OSA was significantly more prevalent than in P-NGT women (73 versus 27 percent; P = 0.01). A diagnosis of GDM was associated with a diagnosis of OSA, even after adjusting for pre-pregnancy body mass index (odds ratio, 6.60).

"Sleep is more disturbed in GDM than in P-NGT women," the authors conclude.

Abstract (http://jcem.endojournals.org/content/early/2013/08/20/jc.2013-2348.abstract )Full Text (subscription or payment may be required) (http://jcem.endojournals.org/content/early/2013/08/20/jc.2013-2348.full.pdf+html )